HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → (+/-)-7-Chloro-1-(2-hydroxyethyl)-2-methyl-4h-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 7-Chloro-1-(2-hydroxyethyl)-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-one | HCID 22003591 | — |
| Catalyst | Acetone | HCID 180 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (+/-)-7-Chloro-1-(2-hydroxyethyl)-2-methyl-4h-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol | HCID 22003582 | — |
Reaction Steps
A mixture of the product of step (i) (0.79 g) in ethanol (100 ml) was treated with sodium borohydride (0.207 g) followed by heating at reflux for 4 hours. The mixture was treated with a few drops of acetone and then concentrated under reduced pressure to dryness. Used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06218376B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-b66e2b2a9e4341a1a088fc45133d9dea |
| Source note | uspto-grants-2001_04 |