Lawesson's reagent → HCID 22003638, compound

HRID 324512Notes

Reaction equation

HRID 324512 reaction equation
[C:1]([O:4][CH2:5][CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][C:14]3[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:15]=3[CH:16]([C:17]3[C:18](=O)[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:10]=2[N:9]=[C:8]1[CH3:31])(=[O:3])[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:41])=CC=1>>[C:1]([O:4][CH2:5][CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][C:14]3[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:15]=3[CH:16]([C:17]3[C:18](=[S:41])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:10]=2[N:9]=[C:8]1[CH3:31])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 22003605HCID 22003605, compound

Product 1

HCID 22003638HCID 22003638, compound

Procedure

The title compound was prepared from the product of step (iv) (0.3 g) and Lawesson's reagent (1.376 g) according to the method of example 34 step (iv). Purification was by biotage chromatography on silica eluting with 3% methanol in dichloromethane with 1% 0.880 ammonia present to give a yellow glass.

Workup

  1. customPurification
  2. customto give a yellow glass

Sources & evidence

ORD record
ord-079703956d0c445fa696b034399ac2cc
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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