HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-1H-indole-6-carboxylic acid → 3-Chloro-N-[(R)-1-phenyl-2-[3-(piperidin-1-yl)propoxy]-ethyl]-1H-indole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-1H-indole-6-carboxylic acid | HCID 15543042 | — |
| Reactant | (R)-1-phenyl-2-[3-(piperidin-1-yl)propoxy]ethylamine | HCID 69307910 | — |
| Product | 3-Chloro-N-[(R)-1-phenyl-2-[3-(piperidin-1-yl)propoxy]-ethyl]-1H-indole-6-carboxamide | HCID 69313216 | — |
Reaction Steps
Using coupling method A, (R)-1-phenyl-2-[3-(piperidin-1-yl)propoxy]ethylamine (218 mg, 0.83 mmol) and 3-chloro-indole-6-carboxylic acid (179 mg, 0.91 mmol) afforded, after purification (SiO2: 50% EtOAc in hexane), 115 mg (32%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-047ba596d8bd4a82b112b732fbbde452 |
| Source note | uspto-grants-2008_09 |