HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Hydroxyimino)-4-phenylbutanoic acid → 1-(4-Isopropylpiperazin-1-yl)-4-phenylbutane-1,4-dione 4-oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Hydroxyimino)-4-phenylbutanoic acid | HCID 231936 | — |
| Reactant | 1-Isopropylpiperazine dihydrochloride | HCID 12268378 | — |
| Product | 1-(4-Isopropylpiperazin-1-yl)-4-phenylbutane-1,4-dione 4-oxime | HCID 86603602 | — |
Reaction Steps
Using coupling method A, 4-hydroximino-4-phenylbutyric acid (500 mg, 2.6 mmol) and 1-isopropylpiperazine dihydrochloride (521 mg, 2.6 mmol) afforded, after purification (SiO2: 10% isopropylamine in EtOAc), 730 mg (89%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-5ee8ce0057a141558d8a7a003d34a7f0 |
| Source note | uspto-grants-2008_09 |