反应详情

While cooling with ice, and under an argon atmosphere, 240 ml of thionyl chloride are added dropwise to 300 ml of abs. methanol, after which 40 g (150 mmol) of (2S)-2-amino-5-benzyloxycarbonylaminopentanoic acid (1.1) are added and the mixture is allowed to react at room temperature for 3 h and at 4° C. overnight. The solution is poured into methyl tert-butyl ether, the solvent is decanted off and the residue is triturated with diethyl ether. After filtering off with suction, 29.14 g (61%) of (1.2) are obtained as a colorless solid.

1. temperatureWhile cooling with ice
2. customto react at room temperature for 3 h and at 4° C. overnight
3. customthe solvent is decanted off
4. customthe residue is triturated with diethyl ether
5. filtrationAfter filtering off with suction, 29.14 g (61%) of (1.2)
6. customare obtained as a colorless solid