HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → N-[(R)-2-[(1-Isopropylpiperidin-4-ylmethyl)(methyl)amino]-1-phenylethyl]carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | N-[(R)-2-[(1-Isopropylpiperidin-4-ylmethyl)amino]-1-phenyl-ethyl]carbamic acid tert-butyl ester | HCID 69307988 | — |
| Product | N-[(R)-2-[(1-Isopropylpiperidin-4-ylmethyl)(methyl)amino]-1-phenylethyl]carbamic acid tert-butyl ester | HCID 69310514 | 98% |
Reaction Steps
Using alkylation method B, N-[(R)-2-[(1-isopropyl-piperidin-4-ylmethyl)amino]-1-phenylethyl]carbamic acid tert-butyl ester (511 mg, 1.4 mmol) and paraformaldehyde (816 mg, 27 mmol) afforded 522 mg (98%) of the title compound as a crude residue that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-d528d99cb90e443ba64545e70e4a690f |
| Source note | uspto-grants-2008_09 |