Water → HCID 10921070, compound

Participants

Reaction Conditions

Reaction Steps

36.6 g of (2-methoxyphenyl)acetic acid, in suspension in 110 cm3 of bis(dimethylamino)methane, were cooled to a temperature in the region of 0° C. 110 cm3 of acetic anhydride were added dropwise, the temperature of the reaction mixture not exceeding 40° C. The reaction mixture was stirred for 24 hours at a temperature in the region of 20° C. and then cooled to a temperature in the region of 0° C. 500 cm3 of distilled water were then added and stirring was continued for 2 hours at a temperature in the region of 0° C. The solid which had appeared was separated by filtration, washed with three times 100 cm3 of distilled water and dried under reduced pressure at 40° C. 23 g of 2-(2-methoxyphenyl)propenoic acid were thus obtained in the form of a cream solid, the characteristics of which were as follows:

Provenance & Evidence