反应详情

To a suspension of 4-aminoacetophenone 1 (74 g, 547 mmol) in toluene (700 mL), acetic anhydride (56 mL 593 mmol) was added dropwise at room temperature. Soon after added all of acetic anhydride, the reaction mixture became a clear solution and then rapidly began to make a white precipitation. The precipitation were filtrated and washed with a small amount of toluene then dried under reduced pressure to afford 2 as a white solid (93 g, 960% yield): MS(ES) m/e 178 [M+H].

1. additionwas added dropwise at room temperature
2. customa white precipitation
3. customThe precipitation
4. filtrationwere filtrated
5. washwashed with a small amount of toluene
6. customthen dried under reduced pressure