反应详情

At room temperature, to the mixture of 4-(4-acetamidophenyl)-2-amino-3-cyanofurane 5 (6.0 g, 25 mmol) in acetic acid (60 mL), diethoxymethyl acetate (41 mL, 25 mmol) was added dropwise. The mixture was stirred at room temperature for 30 min and then concentrated (below 40° C. in water bath). The residual paste was dried up with a pump. The dried solid material was triturated with ether then filtrated to afford 6 (3.93 g) as a solid. MS(ES) m/e 298 [M+H].

1. additionwas added dropwise
2. concentrationconcentrated (below 40° C. in water bath)
3. customThe residual paste was dried up with a pump
4. customThe dried solid material was triturated with ether
5. filtrationthen filtrated