反应详情

温度

60 °C

Compound 3-(4-acetamidophenyl)-4-aminofuro[2,3-d]pyrimidine 8 (242 mg) was dissolved in 2 M potassium hydroxide in the mixture of EtOH (16 mL) and water (4 mL). The mixture was heated (60° C.) for 24 h then concentrated in vacuo. Residual oil was triturated with cold water (6 mL) to give precipitation, which was filtrated, washed with water, and dried under the reduced pressure. The compound 9 (118 mg) as pale orange colored was obtained. MS(ES) m/e 227M+H].

1. concentrationthen concentrated in vacuo
2. customResidual oil was triturated with cold water (6 mL)
3. customto give
4. customprecipitation, which
5. filtrationwas filtrated
6. washwashed with water
7. customdried under the reduced pressure