HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Bromoacetophenone → (R)-1-(4-Bromophenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Bromoacetophenone | HCID 7466 | — |
| Reactant | 1-(4-Bromophenyl)ethanol | HCID 95352 | — |
| Reactant | (S)-4-Bromo-alpha-methylbenzyl alcohol | HCID 2734890 | — |
| Product | (R)-1-(4-Bromophenyl)ethanol | HCID 6950173 | 57% |
Reaction Steps
As shown here, the biochemical conversion reaction of immobilized buckwheat protein for the substrate (±)-1-(4-bromophenyl)ethanol (200 mg) requires 11 days by going through bioconversion to 4-bromoacetophenone accompanying sterically selective oxidation of (S)-1-(4-bromophenyl)ethanol to obtain 114 mg of (R)-1-(4-bromophenyl)ethanol at a yield of 57%. Optical purity was obtained at 88% e.e.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06218581B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-5816d348e29d46978f9c34b11d25b27b |
| Source note | uspto-grants-2001_04 |