p-Nitroacetophenone → (1S)-1-(4-nitrophenyl)ethan-1-ol

Participants

Reaction Steps

As shown here, the biochemical conversion reaction of immobilized buckwheat protein for the substrate (±)-1-(4-nitrophenyl)ethanol (200 mg) requires 17 days by going through bioconversion to 4-nitroacetophenone accompanying sterically selective oxidation of (R)-1-(4-nitrophenyl)ethanol to obtain 50 mg of (S)-1-(4-nitrophenyl)ethanol at a yield of 25%. Optical purity was obtained at 99% e.e.

Provenance & Evidence