HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-Phenylpropyl 4-chloroacetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Benzenepropanol | HCID 31234 | — |
| Reactant | Ethyl 4-chloroacetoacetate | HCID 69484 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Phenylpropyl 4-chloroacetoacetate | HCID 22005546 | 103.1% |
Reaction Steps
A solution of ethyl 4-chloroacetoacetate (134 g, 815 mmol) and 3-phenyl-1-propanol (111 mL, 821 mmol) was heated in toluene, with azeotropic removal of ethanol, for 4 h. The solution was allowed to cool with stirring for 18 h and was then concentrated to give the title compound (214 g). Electrospray MS m/z 219 [M−Cl+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06218538B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-f5352ec59bc440e697415c4146131173 |
| Source note | uspto-grants-2001_04 |