反应详情

To a solution of 4-methoxybenzonitrile (10.0 g) in methanol (75 ml) was added sodium methoxide (0.41 g) and the reaction was stirred at room temperature for 5 days. Ammonium chloride (4.6 g) was added and the reaction was stirred overnight. The reaction was filtered and the filtrate concentrated to an oil. After the addition of ether the off-white precipitate was collected and dried to yield the title compound (3.77 g). Electrospray MS m/z 151 [M+H]+.

1. stirringthe reaction was stirred overnight
2. filtrationThe reaction was filtered
3. concentrationthe filtrate concentrated to an oil
4. additionAfter the addition of ether the off-white precipitate
5. customwas collected
6. customdried