2,6-Diethyl-3-hydroxymethyl4-phenyl-5-(1-ethenyl)pyridine → 2,5,6-Triethyl-3-hydroxymethyl-4-phenylpyridine

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Reaction Steps

The title compound was prepared from 2,6-diethyl-3-hydroxymethyl-4-phenyl-5-(1-ethenyl)pyridine (Example 8) according to the procedure described in Example 1, Step H. 1H NMR (300 MHz, CDCl3): δ7.44 (m, 3 H), 7.18 (m, 2 H), 4.33 (d, J=6 Hz, 2 H), 2.97 (q, J=8 Hz, 2 H), 2.86 (q, J=8 Hz, 2 H), 2.36 (q, J=328 Hz, 2 H), 1.34 (m, 7 H), 0.93 (t, J=8 Hz, 3 H). FAB-MS: calculated for (C18H23NO) 269, found 270 (M+H). Anal. Calcd for C18H23NO: C, 80.26; H, 8.61; N, 5.20. Found: C, 79.70; H, 8.54; N, 5.08. mp 100° C. Rf=0.4 (50% ethyl acetate/hexane).

Provenance & Evidence