HCID 54117268, compound → HCID 22005339, compound

HRID 324807Notes

Reaction equation

HRID 324807 reaction equation
[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:7]([CH:19]=[CH:20][CH:21]([CH3:23])[CH3:22])=[C:6]([CH:24]([CH3:26])[CH3:25])[N:5]=1)([CH3:3])[CH3:2]>C(OCC)(=O)C.CCCCCC>[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=2)[C:7]([CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[C:6]([CH:24]([CH3:26])[CH3:25])[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 54117268HCID 54117268, compound

Product 1

HCID 22005339HCID 22005339, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared from 2,6-diisopropyl-3-hydroxymethyl-4-(4fluorophenyl)-5-(3-methyl-1-butenyl)pyridine (Example 27) according to the procedure described in Example 1, Step H. 1H NMR (300 MHz, CDCl3): δ7.14 (m, 4 H) 4.33 (d, J=5.5 Hz, 2 H), 3.41 (sept, J=6.6 Hz, 1 H), 3.22 (sept, J=6.6 Hz, 1 H), 2.27 (m, 2 H), 1.35 (m, 1 H), 1.33 (d, J=7 Hz, 6 H), 1.30 (d, J=7 Hz, 6 H), 1.17 (m, 3 H), 0.70 (d, J=6.6 Hz, 6 H). FAB-MS: calculated for (C23H32FNO) 357, found 358 (M+H). Anal. Calcd for C23H32FNO: C, 77.27; H, 9.02; N, 3.92. Found: C, 77.34; H, 9.15; N, 3.69. mp 43-45° C. Rf=0.2 (20% ethyl acetate/hexane).

Sources & evidence

ORD record
ord-73503bc4d44c4b8b9614649c0bb37431
Source dataset
uspto-grants-2001_04
Patent number
US06218431B1

Reaction notes

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