2,6-Diisopropyl-3hydroxymethyl-4-(4-fluorophenyl)-5-[2(E)-phenyl-ethenyl]pyridine → 2,6-Diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5-(2-phenylethyl)pyridine

Participants

Reaction Steps

The title compound was prepared from 2,6-diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-[2(E)-phenylethenyl]pyridine (Example 34) according to the procedure described in Example 1, Step H. 1H NMR (300 MHz, CDCl3): δ7.19 (m, 7 H), 6.86 (m, 2 H), 4.36 (d, J=5.5 Hz, 2 H), 3.44 (sept, J=6.6 Hz, 1 H), 3.35 (sept, J=6.6 Hz, 1 H), 2.58 (m, 4 H), 1.35 (d, J=6.6 Hz, 6 H), 1.34 (d, J=6.6 Hz, 6 H), 1.19 (t, J =5.5 Hz, 1 H). FAB-MS: calculated for (C26H30FNO) 391, found 392 (M+H). Anal. Calcd for C26H30FNO: C, 79.76; H, 7.72; N, 3.58. Found: C, 79.57; H, 7.61; N, 3.44. mp 158-159° C. Rf=0.3 (20% ethyl acetate/hexane).

Provenance & Evidence