Ethyl acetate hexane → HCID 67484911, compound

Participants

Reaction Steps

The title compound was prepared from 2,6diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5-[2(E)-(4-methylphenyl)ethenyl]pyridine (Example 42 ) according to the procedure described in Example 1, Step H. 1H NMR (300 MHz, CDCl3): δ7.17 (m, 4 H), 7.02 (d, J=7.7 Hz, 2 H), 6.75 (d, J=7.7 Hz, 2 H), 4.36 (d, J=4 Hz, 2 H), 3.43 (sept, J=6.6 Hz, 1 H), 3.34 (sept, J=6.6 Hz, 1 H), 2.55 (m, 4 H), 2.29 (s, 3 H), 1.34 (d, J=6.6 Hz, 6 H), 1.33 (d, J=6.6 Hz, 6 H), 1.20 (m, 1 H). FAB-MS: calculated for (C27H32FNO) 405, found 406 (M+H). Anal. Calcd for C27H32FNO: C, 79.96; H, 7.95; N, 3.45. Found: C, 79.40; H, 7.84; N, 3.44. mp 121-123° C. Rf=0.3 (20% ethyl acetate/hexane). vl)propyllpyridine

Provenance & Evidence