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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 324816Generated: October 30, 2026

4-Fluorobenzaldehyde → Methyl 4-(4-fluorophenyl)-5-(hydroxymethyl)-2,6-di(propan-2-yl)pyridine-3-carboxylate

https://huagongshe.com/reaction/324816

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-FluorobenzaldehydeHCID 68023—
ReactantAmmonium AcetateHCID 517165—
ReactantMethyl 4-methyl-3-oxopentanoateHCID 2759969—
ProductMethyl 4-(4-fluorophenyl)-5-(hydroxymethyl)-2,6-di(propan-2-yl)pyridine-3-carboxylateHCID 22004908—

Reaction Steps

Prepared from methyl isobutyrylacetate, 4-fluorobenzaldehyde and ammonium acetate by the procedures described in Example 1, Steps A-D.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06218431B1
Source datasetuspto-grants-2001_04
ORD IDord-dcbb50dafd034dc29239faca6dcaf9ea
Source noteuspto-grants-2001_04