Methylenechloride Hexane → HCID 22005250, compound

HRID 324828Notes

Reaction equation

[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:7]([CH2:19][CH2:20][CH2:21][CH3:22])=[C:6]([CH:23]([CH3:25])[CH3:24])[N:5]=1)([CH3:3])[CH3:2].[CH2:26](Cl)Cl.CCCCCC>>[CH:1]([C:4]1[C:9]([CH:10]([OH:11])[CH3:26])=[C:8]([C:12]2[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=2)[C:7]([CH2:19][CH2:20][CH2:21][CH3:22])=[C:6]([CH:23]([CH3:24])[CH3:25])[N:5]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 21226440Methylenechloride Hexane

HCID 22005107HCID 22005107, compound

Product 1

HCID 22005250HCID 22005250, compound

Procedure

The title compound was prepared from 2,6-diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5butylpyridine (Example 24) according to the procedures described in Example 101. 1H NMR (300 MHz, CDCl3): δ 7.1 (m, 4 H), 4.7 (dq, J=3 Hz, 1 H), 3.7 (septet, J=7 Hz, 1 H), 3.2 (septet, J=7 Hz, 1 H), 2.2 (t, J=1.5 Hz, 2 H), 1.6 (d, J=5 Hz, 1 H), 1.4 (d, J=7 Hz, 3 H), 1.3 (m, 16 H), 0.8 (t, J=7Hz, 3H). FAB-MS: calcd for (C23H32FNO) 357, found 358 (M+H). mp 103-104° C. Rf=0.2 (60% CH2Cl2/hexane).

Sources & evidence

ORD record: ord-896e09a96ab440c98910bfe08efaf9a4
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06218431B1

Reaction notes

Loading…