Ethylamine → 2,6-Diisopropyl-3-(ethylamino)methyl-4-(4-fluorophenyl)-5-pentylpyridine

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Reaction Steps

The title compound was prepared from 2,6-diisopropyl-4-(4-fluorophenyl)-5-pentyl-3-pyridinecarboxaldehyde (Example 114, Step A) and ethylamine, according to the procedures described in Example 120. 1H NMR (300 MHz, CDCl3): δ 7.06 (m, 4 H), 3.18 (m, 4 H), 2.32 (q, J=7.4 Hz, 2 H), 2.15 (t, J=5.2 Hz, 2 H), 1.13 (m, 18 H), 0.839 (t, J=7.4 Hz, 3 H), 0.698 (t, J=6.6 Hz, 3 H). FAB-MS: calcd for (C25H37FN2) 384, found 385 (M+H). Anal. Calcd for C23H37FN2: C, 78.08; H, 9.70; N, 7.28; F, 4.94. Found: C, 77.85; H, 9.50; N, 6.99; F, 4.79. mp 48-50° C. Rf=0.1 (20% ether/CH2Cl2).

Provenance & Evidence