HCID 54185295, compound → HCID 22005388, compound

HRID 324839Notes

Reaction equation

HRID 324839 reaction equation
[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[C:7]([CH:19]=[CH:20][CH2:21][CH2:22][CH3:23])=[C:6]([CH:24]([CH3:26])[CH3:25])[N:5]=1)([CH3:3])[CH3:2]>C(OCC)(=O)C.CCCCCC>[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[C:7]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:6]([CH:24]([CH3:25])[CH3:26])[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 54185295HCID 54185295, compound

Product 1

HCID 22005388HCID 22005388, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared from 2,6-diisopropyl-3-hydroxymethyl-4-(3-fluorophenyl)-5-(pent-1-enyl)pyridine (Example 127) by the procedure described in Example 126. 1H NMR (300 MHz, CDCl3): δ 0.79 (t, J=7.0 Hz, 3 H), 1.10-1.35 (m, 18 H), 2.28 (m, 2 H), 3.24 (m, 1 H), 3.42 (m, 1 H), 4.33 (s, 2 H), 6.96 (m, 2 H), 7.12 (m, 1 H), 7.40 (m, 1 H). mp 117-118° C. Rf=0.36 (10% ethyl acetate/n-hexane).

Sources & evidence

ORD record
ord-629b0425d0494250b7003151b8f4d415
Source dataset
uspto-grants-2001_04
Patent number
US06218431B1

Reaction notes

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