HCID 53747569, compound → HCID 22005096, compound

HRID 324844Notes

Reaction equation

HRID 324844 reaction equation
[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[C:7]([CH:21]=[CH:22][CH2:23][CH2:24][CH3:25])=[C:6]([CH:26]([CH3:28])[CH3:27])[N:5]=1)([CH3:3])[CH3:2]>C(OCC)(=O)C.CCCCCC>[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:13]=[CH:14][C:15]([CH:18]([CH3:19])[CH3:20])=[CH:16][CH:17]=2)[C:7]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[C:6]([CH:26]([CH3:27])[CH3:28])[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 53747569HCID 53747569, compound

Product 1

HCID 22005096HCID 22005096, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared from 2,6-diisopropyl-3-hydroxymethyl-4-(4-isopropylphenyl)-5-(pent-1-enyl)pyridine (Example 133) by the procedure described in Example 126. 1H NMR (300 MHz, CDCl 3): δ 0.74 (t, J=7.0 Hz, 3 H), 1.0-1.40 (m, 25 H), 2.25 (m, 2 H), 2.95 (m, 1 H), 3.25 (m, 1 H), 3.40 (m, 1 H), 4.35 (d, J=6.0 Hz, 2 H), 7.1, (d, J=8.5 Hz, 2 H), 7.25 (d, J=8.5 Hz, 2 H). FAB-MS: calculated for C26H39NO 382; found 382 (M+H, 100%). Rf=0.40 (10% ethyl acetate/n-hexane). mp 42-44° C.

Sources & evidence

ORD record
ord-7f89ae5231f54c9689806535d6004c28
Source dataset
uspto-grants-2001_04
Patent number
US06218431B1

Reaction notes

Loading…