HCID 54242235, compound → HCID 22004896, compound

Participants

Reaction Steps

The title compound was prepared from 2,6-diisopropyl-3-hydroxymethyl-4-(3-furyl)-5-(pent-1-enyl)pyridine (Example 187) in 6% yield by the methods described in Example 125. FAB-MS: calculated for C21H31NO2 329; found 330 (M+1). 1H NMR (300 MHz, CD3OD): δ 0.83 (t, J=6.8 Hz, 3 H), 1.19-1.36 (m, 19 H), 2.42-2.48 (m, 2 H), 3.25 (septet, J=6.6 Hz, 1 H, 3.45 (septet, J=6.6 Hz, 1 H), 4.38 (s, 2 H), 6.42 (m, 1 H), 7.45-7.46 (m, 1 H), 7.61-7.62 (t, J=1.7 Hz, 1 H). Anal. calc for C21H31NO2: C, 76.55; H, 9.48; N, 4.25. Found: C, 76.41; H, 9.76; N, 4.24. Rf=0.59 (20% EtOAc/hex). mp 98-100 ° C.

Provenance & Evidence