Acetic Anhydride → HCID 22005239, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the intermediate obtained in Example 199, Step B (4.8 g, 7.97 mmol) and acetic anhydride (20 mL) was heated to 100° C. for 20 min. The mixture was poured onto ice and the aqueous phase extracted with ethyl acetate (3×30 mL). The combined organic phase was washed with saturated aqueous sodium bicarbonate solution (3×50 mL), and saturated aqueous sodium chloride solution (3×50 mL). Silica gel chromatography provided a yellow oil (4.4 g, 90%). 1H NMR (300 MHz, CDCl3): δ 7.40 (m, 6H), 7.31 (m, 4H), 7.06 (m, 4H), 5.29 (s, 2H), 4.26 (s, 2H), 3.14 (sept, 6.8 Hz, 1H), 2.2 (m, 2H), 2.18 (s, 3H), 1.2 (m, 2H), 1.16 (d, 6.6 Hz, 6H), 1.05 (m, 4H), 0.99 (s, 9H), 0.77 (t, 6.8 Hz, 3H).

Provenance & Evidence