3-Chloropropanesulphonyl chloride → HCID 10740750, compound

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Reaction Steps

The title compound was prepared according to the procedure of example 3 except that 1,3-dibutyl-8-methyl-3,7-dihydro-purine-2,6-dione was used in place of 1,3-dibutyl-3,7-dihydro-purine-2,6-dione and 3-chloropropanesulfonyl chloride was used in place of methanesulfonyl chloride. Yield: 71%: mp: 76-78° C.; 1H NMR (300 MHz, CDCl3): δ 0.92-0.99 (m, 6H), 1.33-1.42 (m, 4H), 1.57-1.65 (m, 2H), 1.67-1.74 (m, 2H), 2.32-2.41 (m, 2H) 2.74 (s, 3H), 3.69 (t, J=6.2 Hz, 2H), 3.99 (t, J=7.6 Hz, 2H), 4.08 (t, J=7.5 Hz, 2H), 4.23 (t, J=7.5 Hz, 2H); IR (KBr, cm−1): 2959m, 2874m, 1705s, 1620w, 1537m, 1522s, 1485m, 1183s, 1121s, 938m, 751m, 570m; MS (ES) m/z (relative intensity): 419 (M++H, 100).

Provenance & Evidence