反应详情

温度

25 °C

A solution of 6-nitro-1-indanone (18.9 g, 107 mmol) in methanol (300 mL) was cooled to 0° C. and sodium borohydride (4.04 g, 107 mmol) was added in several small portions. The reaction was then stirred overnight at 25° C. The solution was quenched at 0° C. with methanolic hydrochloric acid (200 mL), concentrated under reduced pressure, redissolved in dichloromethane, washed with water, and the organic layer reconcentrated to provide the crude alcohol as a brown solid which was used without further purification in Preparation 3.

1. customThe solution was quenched at 0° C. with methanolic hydrochloric acid (200 mL)
2. concentrationconcentrated under reduced pressure
3. dissolutionredissolved in dichloromethane
4. washwashed with water