Cyclopropanecarbonyl chloride, 1-[3-(trifluoromethyl)phenyl]- → HCID 178507155, compound

HRID 32499Notes

Reaction equation

HRID 32499 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([C:9]2([C:12](Cl)=[O:13])[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[NH2:17][C:18]1[N:23]([C:24]2[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)[CH2:22][N:21]=[C:20]2[S:31][CH:32]=[CH:33][C:19]=12>>[NH2:17][C:18]1[N:23]([C:24]2[CH:25]=[CH:26][C:27]([NH:30][C:12]([C:9]3([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:16])([F:15])[F:1])[CH:4]=4)[CH2:11][CH2:10]3)=[O:13])=[CH:28][CH:29]=2)[CH2:22][N:21]=[C:20]2[S:31][CH:32]=[CH:33][C:19]=12

Participants

3

Reactant 2

HCID 83411976Cyclopropanecarbonyl chloride, 1-[3-(trifluoromethyl)phenyl]-HCID 178507154HCID 178507154, compound

Product 1

HCID 178507155HCID 178507155, compound

Procedure

The compound was prepared following the procedure described in Example 469, using 1-(3-Trifluoromethyl-phenyl)-cyclopropanecarbonyl chloride as the acid chloride of choice, and 4-Amino-3-(4-aminophenyl)thieno[2,3-d]pyrimidine as the diamine of choice. MS(ES) m/e 455 [M+H]+.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-7b5a653f84414b5ebc0df22d710ddbd0
Source dataset
uspto-grants-2008_09
Patent number
US07427623B2

Reaction notes

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