4-(Chlorosulfonyl)benzoic acid → 4-[4'-(2-Benzyl-benzofuran-3-yl)-biphenyl-4-yloxysulfonyl]-benzoic acid

HRID 325008Notes

Reaction equation

HRID 325008 reaction equation
[CH2:1]([C:8]1[O:9][C:10]2[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=2[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=2)=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[S:31]([C:34]1[CH:42]=[CH:41][C:37]([C:38]([OH:40])=[O:39])=[CH:36][CH:35]=1)(=[O:33])=[O:32]>>[CH2:1]([C:8]1[O:9][C:10]2[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=2[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][S:31]([C:34]3[CH:35]=[CH:36][C:37]([C:38]([OH:40])=[O:39])=[CH:41][CH:42]=3)(=[O:33])=[O:32])=[CH:21][CH:20]=2)=[CH:15][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 823854-(Chlorosulfonyl)benzoic acidHCID 105475454'-(2-Benzyl-benzofuran-3-yl)-biphenyl-4-ol

Product 1

HCID 98507834-[4'-(2-Benzyl-benzofuran-3-yl)-biphenyl-4-yloxysulfonyl]-benzoic acid

Procedure

The title compound was prepared from 4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-ol and 4-chlorosulfonyl-benzoic acid, in substantially the same manner, as described in Example 1 step g, and was obtained as a white solid, mp 186-188° C.; MS m/e 559 (M-H)+;

Workup

  1. customwas obtained as a white solid, mp 186-188° C.

Sources & evidence

ORD record
ord-5997da43529e4448afa65aedda151ddb
Source dataset
uspto-grants-2001_04
Patent number
US06221902B1

Reaction notes

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