化工社化工社 化学情報印刷レポート · 研究参考用
2-Amino-o-cresol → 3-t-Butoxycarbonylamino-2-methylphenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-o-cresol | HCID 104448 | — |
| 反応物 | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-t-Butoxycarbonylamino-2-methylphenol | HCID 22033487 | 69% |
反応手順
3-Amino-2-methylphenol (2.0 g; 16 mmol) and di-t-butylcarbonate were dissolved in THF (20 mL) and refluxed overnight. Evaporation of the solvent followed by flash chromatography (SiO2; EtOAc 5-30% in isohexane) afforded 2.48 g (69%) of the sub-title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06221898B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-14d40c7fbec645dd81d48e97be74a956 |
| 出典メモ | uspto-grants-2001_04 |