HCID 22033504, compound → HCID 22033482, compound

Participants

Reaction Steps

t-Butyloxycarbonylamino-3-[2-(4-cyanophenyl)ethoxy]-5-methylbenzene (1.55 g; 4.4 mmol; from step (ii) above) was stirred in a mixture of trifluoroacetic acid (10 mL) and methylene chloride (10 mL) for 3 hours. The solvent was removed in vacuo. The residue was dissolved in EtOAc (50 mL), washed with Na2CO3/aq (sat.) and water, dried (Na2CO3) and the solvent was removed to afford a yellow oil, which crystallized upon standing. Yield: 1.19 g (100%).

Provenance & Evidence