HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → Amino-3-[2-(4-cyanophenyl)ethylthio]benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Aminothiophenol | HCID 31577 | — |
| Reactant | HCID 22033501 | HCID 22033501 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Amino-3-[2-(4-cyanophenyl)ethylthio]benzene | HCID 22033546 | 49% |
Reaction Steps
3-Aminothiophenol (0.87 g; 7.0 mmol), 4-toluenesulfonic acid-2-(4-cyano-phenyl) ethyl ester (2.0 g; 6.6 mmol; from step (i) above) and K2CO3 (1 g) were stirred in a mixture of EtOH (10 mL) and CH2Cl2 for 4 hours. Addition of ether, washing with brine and 2M aqueous NaOH, drying (MgSO4), evaporation of the solvent and flash chromatography (SiO2; Et2O:hexane (1:1)) afforded 0.82 g (49%) of the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06221898B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-5fb81c08a4a84b14bfa1ca90758e419a |
| Source note | uspto-grants-2001_04 |