反应详情

BBr3 (26 mL; 0.275 mmol) was added to a solution of chloro-3,5-dimethyoxybenzene (10 g; 30 mmol) in CH2Cl2 (100 mL) at −70° C. The cooling bath was removed and the solution was stirred at room temperature for 4 days. After re-cooling to −70° C., MeOH was added (150 mL). After evaporation of the solvent, toluene was added and removed in vacuo. Purification by kugelrohr distillation afforded 9 g (100%) of the sub-title compound.

1. customThe cooling bath was removed
2. temperatureAfter re-cooling to −70° C.
3. additionMeOH was added (150 mL)
4. customAfter evaporation of the solvent, toluene
5. additionwas added
6. customremoved in vacuo
7. customPurification
8. distillationby kugelrohr distillation