4-Cyanobenzoyl chloride → HCID 22002087, compound

HRID 325061Notes

Reaction equation

HRID 325061 reaction equation
[NH2:1][CH2:2][C:3]1[CH:24]=[CH:23][C:6]([O:7][CH2:8][C:9]2([CH2:13][O:14][C:15]3[CH:22]=[CH:21][C:18]([CH2:19][NH2:20])=[CH:17][CH:16]=3)[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[C:25]([C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1)#[N:26]>>[C:25]([C:27]1[CH:35]=[CH:34][C:30]([C:31]([NH:20][CH2:19][C:18]2[CH:17]=[CH:16][C:15]([O:14][CH2:13][C:9]3([CH2:8][O:7][C:6]4[CH:5]=[CH:4][C:3]([CH2:2][NH:1][C:31](=[O:32])[C:30]5[CH:34]=[CH:35][C:27]([C:25]#[N:26])=[CH:28][CH:29]=5)=[CH:24][CH:23]=4)[CH2:10][CH2:11][CH2:12]3)=[CH:22][CH:21]=2)=[O:32])=[CH:29][CH:28]=1)#[N:26]

Participants

3

Reactant 2

HCID 801724-Cyanobenzoyl chlorideHCID 20649520HCID 20649520, compound

Product 1

HCID 22002087HCID 22002087, compoundYield 78%

Procedure

The noted compound was prepared according to procedures above using 4-[1-(4-aminomethyl-phenoxymethyl)-cyclobutylmethoxy]-benzylamine from Example 91 and 4-cyanobenzoyl chloride to yield a yellow foam (1.4 g, 78% yield).

Workup

  1. customThe noted compound was prepared

Sources & evidence

ORD record
ord-866518cc758c4d5f9da149b9232b4032
Source dataset
uspto-grants-2001_04
Patent number
US06221914B1

Reaction notes

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