反应详情

2.5 g (7.3 mmol) of 2-carboethoxyamino-3-carboethoxy-6-acetyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine were heated with 1.7 g (7.3 mmol) of 1-(2-aminoethyl)-4-(2-methoxyphenyl)piperazine at 180° C. for 2 h under nitrogen while stirring the melt efficiently. After cooling, the crude product was purified by column chromatography (silica gel, mobile phase methylene chloride/ methanol 95/5). 0.7 g (20%) of product with melting point 135-137° C. was isoldted.

1. temperatureAfter cooling
2. customthe crude product was purified by column chromatography (silica gel, mobile phase methylene chloride/ methanol 95/5)