2-Furancarboxylic acid, hydrazide → N-(5-Ethoxycarbonyl-2-methylthiopyrimidin-6-yl]-N'-(2-furoyl)hydrazine

HRID 325093Notes

Reaction equation

HRID 325093 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](Cl)=[N:8][C:9]([S:12][CH3:13])=[N:10][CH:11]=1)=[O:5])[CH3:2].[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20]([NH:22][NH2:23])=[O:21]>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[N:10][C:9]([S:12][CH3:13])=[N:8][C:7]=1[NH:23][NH:22][C:20]([C:16]1[O:15][CH:19]=[CH:18][CH:17]=1)=[O:21])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 187312-Furancarboxylic acid, hydrazideHCID 800084-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester

Product 1

HCID 17919651N-(5-Ethoxycarbonyl-2-methylthiopyrimidin-6-yl]-N'-(2-furoyl)hydrazine

Procedure

Compound ee was obtained using 5-ethoxycarbonyl-4-chloro-2-methylthiopyrimidine and 2-furoic hydrazide in the same manner as in Reference Example 19.

Workup

  1. customCompound ee was obtained

Sources & evidence

ORD record
ord-41e3d4b668ed4aaa9e26a80c866b0ed5
Source dataset
uspto-grants-2001_04
Patent number
US06222035B1

Reaction notes

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