HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 1-Methyl-4-phenyl-1H-imidazole-5-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-Methyl-4-phenyl-1H-imidazole-5-carboxylic acid | HCID 17965794 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Methyl-4-phenyl-1H-imidazole-5-carbonyl chloride | HCID 17965820 | — |
Reaction Steps
Oxalyl chloride (0.35 mL) followed by one drop of DMF was added to 1-methyl-4-phenyl-1H-imidazole-5-carboxylic acid (intermediate 3) (732 mg) suspended in anhydrous DCM (6 mL). After stirring for 1 hour under inert atmosphere the mixture was evaporated to dryness and used immediately without further purification (800 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427616B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-7b4d297f016240178742906260432329 |
| Source note | uspto-grants-2008_09 |