Triethylamine → HCID 9976683, compound

Participants

Reaction Steps

To the compound of Example 4, described above (79 mg, 0.26 mmol) in CH2Cl2 (0.5 mL) was added Et3N (72 uL, 0.52 mmol), and then methanesulfonyl chloride (25 uL, 0.31 mmol). The reaction exothermed to CH2Cl2 reflux briefly. The reaction was over within 1 min based on tlc (19:1 CH2Cl2/MeOH) and was poured into 10% NaOH (5 mL) and extracted with EtOAc (3×20 mL). The extracts were washed with H2O (10 mL) and satd aq Nacl (10 mL), dried (Na2SO4), concentrated and flash chromatographed (1×10 cm silica) with 0-8% MeOH in CH2Cl2 to afford 63 mg (65%). mp=186-187°.

Provenance & Evidence