Ethanol → Ethyl 2-(chloromethyl)benzoate

HRID 325117ノート

反応式

HRID 325117 の反応式
[Cl:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=[O:6].[CH2:12]([OH:14])[CH3:13]>CO>[CH2:12]([O:14][C:5](=[O:6])[C:4]1[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=1[CH2:2][Cl:1])[CH3:13]

参加物

4

反応物 2

HCID 702EthanolHCID 30163952-(Chloromethyl)benzoyl chloride

生成物 1

HCID 12937460Ethyl 2-(chloromethyl)benzoate収率 90%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a double-neck 500 ml flask equipped with cooler, thermometer and dropping funnel was added 180 g of o-(chloromethyl)benzoic acid chloride, and then 60 ml of ethanol was further added dropwise, while maintaining the internal temperature of reactor at 40˜50° C. After all amounts of methanol were infused, the reacting mixture was stirred for 10 hours, while maintaining the internal temperature of a reactor at 40˜50° C. After a distiller was equipped immediately, the residue was subjected to fractional distillation under reduced pressure to afford 179 g of desired compound (yield 90%) as oil.

後処理

  1. customTo a double-neck 500 ml flask equipped with cooler, thermometer and
  2. temperaturewhile maintaining the internal temperature of reactor at 40˜50° C
  3. temperaturewhile maintaining the internal temperature of a reactor at 40˜50° C
  4. customAfter a distiller was equipped immediately
  5. distillationthe residue was subjected to fractional distillation under reduced pressure

出典と根拠

ORDレコード
ord-ea7c722dd6a844868deccf730d3c5ad4
出典データセット
uspto-grants-2001_04
特許番号
US06222060B1

反応ノート

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