Ethanol → Ethyl 2-(chloromethyl)benzoate

HRID 325117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 325117
[Cl:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=[O:6].[CH2:12]([OH:14])[CH3:13]>CO>[CH2:12]([O:14][C:5](=[O:6])[C:4]1[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=1[CH2:2][Cl:1])[CH3:13]

Komponenten

4

Edukt 2

HCID 702EthanolHCID 30163952-(Chloromethyl)benzoyl chloride

Produkt 1

HCID 12937460Ethyl 2-(chloromethyl)benzoateAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a double-neck 500 ml flask equipped with cooler, thermometer and dropping funnel was added 180 g of o-(chloromethyl)benzoic acid chloride, and then 60 ml of ethanol was further added dropwise, while maintaining the internal temperature of reactor at 40˜50° C. After all amounts of methanol were infused, the reacting mixture was stirred for 10 hours, while maintaining the internal temperature of a reactor at 40˜50° C. After a distiller was equipped immediately, the residue was subjected to fractional distillation under reduced pressure to afford 179 g of desired compound (yield 90%) as oil.

Aufarbeitung

  1. customTo a double-neck 500 ml flask equipped with cooler, thermometer and
  2. temperaturewhile maintaining the internal temperature of reactor at 40˜50° C
  3. temperaturewhile maintaining the internal temperature of a reactor at 40˜50° C
  4. customAfter a distiller was equipped immediately
  5. distillationthe residue was subjected to fractional distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ea7c722dd6a844868deccf730d3c5ad4
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06222060B1

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