反应详情

To a double-neck 500 ml flask equipped with cooler, thermometer and dropping funnel was added 180 g of o-(chloromethyl)benzoic acid chloride, and then 60 ml of ethanol was further added dropwise, while maintaining the internal temperature of reactor at 40˜50° C. After all amounts of methanol were infused, the reacting mixture was stirred for 10 hours, while maintaining the internal temperature of a reactor at 40˜50° C. After a distiller was equipped immediately, the residue was subjected to fractional distillation under reduced pressure to afford 179 g of desired compound (yield 90%) as oil.

1. customTo a double-neck 500 ml flask equipped with cooler, thermometer and
2. temperaturewhile maintaining the internal temperature of reactor at 40˜50° C
3. temperaturewhile maintaining the internal temperature of a reactor at 40˜50° C
4. customAfter a distiller was equipped immediately
5. distillationthe residue was subjected to fractional distillation under reduced pressure