2-Chloroethanol → HCID 54345004, compound

HRID 325118Notes

Reaction equation

HRID 325118 reaction equation
[Cl:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=[O:6].[Cl:12][CH2:13][CH2:14][OH:15]>>[Cl:12][CH2:13][CH2:14][O:15][C:5](=[O:6])[C:4]1[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=1[CH2:2][Cl:1]

Participants

3

Reactant 2

HCID 342-Chloroethanol2×HCID 30163952-(Chloromethyl)benzoyl chloride

Product 1

HCID 54345004HCID 54345004, compoundYield 94%

Procedure

180 g of o-(chloromethyl)benzoic acid chloride was placed in a double-neck 500 ml flask equipped with a cooler, thermometer and dropping funnel. 50 ml of 2-chloroethanol was added dropwisely, while maintaining the internal temperature of reactor at 40˜50° C. After all amounts of 2-chloroethanol were infused, the reacting solution was stirred for 10 hours, while maintaining the internal temperature of reactor at 40˜50° C. The residue was subjected to fractional distillation under reduced pressure at the reactor equipped with a fractional distiller to afford 165 g of desired compound (yield 94%) as oil.

Workup

  1. customequipped with a cooler
  2. temperaturewhile maintaining the internal temperature of reactor at 40˜50° C
  3. temperaturewhile maintaining the internal temperature of reactor at 40˜50° C
  4. distillationThe residue was subjected to fractional distillation under reduced pressure at the reactor
  5. customequipped with a fractional distiller

Sources & evidence

ORD record
ord-ae690a27eaff407988a1c0a3f6b938ed
Source dataset
uspto-grants-2001_04
Patent number
US06222060B1

Reaction notes

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