反应详情

To a mixture of 150 g dimethyl malonate and 464 g dec-9-en-1-ol, 30 g sodium methoxide (5.4 M in methanol) was dropped in. The mixture was heated to 120° C. to and the methanol formed was distilled off. After 6 hours, the mixture was cooled down, diluted with ether and washed with HCl 2N, saturated sodium bicarbonate and water. The organic phase was dried, filtered and evaporated to dryness. The resulting yellow oil was purified by distillation to yield 258 g of a yellow oil.

1. additionwas dropped in
2. customformed
3. distillationwas distilled off
4. temperaturethe mixture was cooled down
5. additiondiluted with ether
6. washwashed with HCl 2N, saturated sodium bicarbonate and water
7. customThe organic phase was dried
8. filtrationfiltered
9. customevaporated to dryness
10. distillationThe resulting yellow oil was purified by distillation