HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-tert-Butylcyclohexanone → 4-tert-butyl-1,1-difluorocyclohexane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-tert-Butylcyclohexanone | HCID 7392 | — |
| Reactant | 4-Fluoroanisole | HCID 9987 | — |
| Reactant | (Diethylamino)sulfur trifluoride | HCID 123472 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-tert-butyl-1,1-difluorocyclohexane | HCID 640499 | 67% |
Reaction Steps
A reaction of 4-t-butylcyclohexanone (2 mmol) with diethylaminosulfur trifluoride (3.0 mmol) in CH2Cl2 (10 mL) containing TiCl4 (0.3 mmol) at room temperature gave a 99% conversion of starting material to products and a 67% yield of 1,1-difluoro-4-t-butylcyclohexane after 6 h. as determined by NMR (4-fluoroanisole as internal standard).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06222064B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-96b5f1c3e20f4625bf501d7f33ca1c35 |
| Source note | uspto-grants-2001_04 |