HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexaneacetic acid → Cyclohexylacetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexaneacetic acid | HCID 21363 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Cyclohexylacetyl chloride | HCID 2757989 | 66.8% |
Reaction Steps
To a 0° C. solution of cyclohexaneacetic acid (2.12 g, 14.9 mmol) in 30 mL of CH2Cl2 was added two drops of DMF followed by oxalyl chloride (1.3 mL, 14.9 mmol). The solution was warmed to r.t. and stirred overnight. The solvent was remove in vacuo to give 1.60 g of the title compound as a colourless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06222048B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-fe261519795e43c29cc166685eb458dc |
| Source note | uspto-grants-2001_04 |