Sodium Carbonate → HCID 22002655, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the triflate (550 mg, 1.58 mmol) from step 2 in THF (10 ml) and boronic acid from step 3 (318 mg, 1.90 mmol) was added an aq. solution of Na2CO3 (2.0M, 3.16 mmol, 1.60 ml) and Pd(PPh3)4 (91 mg, 0.079 mmol). The mixture was heated for 2 h at 70° C., cooled and poured into sat. aq. NH4Cl. The aq. layer was extracted with Et2O and the combined org. layers were dried over MgSO4. Purification via flash chromatography (20% EtOAc in hexane) gave 460 mg of the title compound as a foam.

Provenance & Evidence