methyl (2S)-2-amino-4-(methylsulfanyl)butanoate → 4-(2-Pyridyloxy)-2-phenylbenzoylmethionine methyl ester

HRID 325209Notes

Reaction equation

HRID 325209 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:9]=1.[CH3:23][O:24][C:25](=[O:32])[C@H:26]([CH2:28][CH2:29][S:30][CH3:31])[NH2:27]>>[CH3:23][O:24][C:25](=[O:32])[C@H:26]([CH2:28][CH2:29][S:30][CH3:31])[NH:27][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][C:8]([O:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[CH:9][C:10]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 64684methyl (2S)-2-amino-4-(methylsulfanyl)butanoateHCID 234365054-(2-Pyridyloxy)-2-phenylbenzoic acid

Product 1

HCID 206227874-(2-Pyridyloxy)-2-phenylbenzoylmethionine methyl ester

Procedure

The resultant product from Example 6C is coupled to methionine methyl ester according to the procedure of Example 1C to give the title compound.

Sources & evidence

ORD record
ord-6dcddf1828d340b8a4f150c924ddf181
Source dataset
uspto-grants-2001_04
Patent number
US06221865B1

Reaction notes

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