HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrous Acid → Methyl 4-fluoro-2-phenylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrous Acid | HCID 24529 | — |
| Reactant | Tetrafluoroboric acid | HCID 28118 | — |
| Reactant | 5-Amino-biphenyl-2-carboxylic acid methyl ester | HCID 15406988 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Product | Methyl 4-fluoro-2-phenylbenzoate | HCID 54170746 | — |
Reaction Steps
A solution of methyl 4-amino-2-phenylbenzoate (1.0 equivalent) in dilute aqueous HBF4 is treated with NaNO2 (1.1 equivalents) until an excess of nitrous acid persists. The mixture is extracted into ethyl acetate which is dried and evaporated. The title ester is purified by chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06221865B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-a59aa93faa34482abdedab2de5b795a3 |
| Source note | uspto-grants-2001_04 |