methyl (2S)-2-amino-4-(methylsulfanyl)butanoate → 4-Fluoro-2-phenylbenzoyl Methionine Methyl Ester

HRID 325211Notes

Reaction equation

HRID 325211 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:3]=1.[CH3:17][O:18][C:19](=[O:26])[C@H:20]([CH2:22][CH2:23][S:24][CH3:25])[NH2:21]>>[CH3:17][O:18][C:19](=[O:26])[C@H:20]([CH2:22][CH2:23][S:24][CH3:25])[NH:21][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([F:1])=[CH:3][C:4]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 64684methyl (2S)-2-amino-4-(methylsulfanyl)butanoateHCID 167687084-Fluoro-2-phenylbenzoic acid

Product 1

HCID 206228304-Fluoro-2-phenylbenzoyl Methionine Methyl Ester

Procedure

The resultant product from Example 13B is coupled to methionine methyl ester according to the procedure of Example 1C to give the title compound.

Sources & evidence

ORD record
ord-6de0f8e678834f25a923d14701743d3d
Source dataset
uspto-grants-2001_04
Patent number
US06221865B1

Reaction notes

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