反应详情

6-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine (intermediate 17) (30 mg) and concentrated NH3 (0.75 mL) were stirred in 1,4-dioxane (3 mL) for 1 hour. The solvent was evaporated and the resultant residue dissolved in a small volume of DCM. Isohexane was then added and the resultant solid filtered and dried in vacuo to give the title compound as a pale yellow solid (25 mg, 100%);

1. customThe solvent was evaporated
2. dissolutionthe resultant residue dissolved in a small volume of DCM
3. additionIsohexane was then added
4. filtrationthe resultant solid filtered
5. customdried in vacuo