HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanedithiol → 4(Aminomethyl)-2-phenylbenzoyl methionine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanedithiol | HCID 8013 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | [4-Azidomethyl-2-phenylbenzoyl]methionine methyl ester | HCID 20622822 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4(Aminomethyl)-2-phenylbenzoyl methionine methyl ester | HCID 20622820 | — |
Reaction Steps
To the resultant compound from Example 18A in methanol is added triethylamine (3.0 equivalent) and propane 1,3-dithiol (3.0 equivalents). After the reaction is judged complete by TLC analysis, the mixture is filtered and evaporated. Chromatography of the residue on silica gel provides the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06221865B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-cea7c16c4ee54640b6a80a886f0dec89 |
| Source note | uspto-grants-2001_04 |