HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diethylamine → {4-[2-(Imidazol-2-yl)ethynyl]-2-phenylbenzoyl}-methionine methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diethylamine | HCID 8021 | — |
| Edukt | (4-Ethynyl-2-phenylbenzoyl)methionine methyl ester | HCID 54338681 | — |
| Edukt | HCID 178418934 | HCID 178418934 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Katalysator | Palladium(2+) acetate--triphenylphosphane (1/2/2) | HCID 84538 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | {4-[2-(Imidazol-2-yl)ethynyl]-2-phenylbenzoyl}-methionine methyl ester | HCID 69930468 | — |
Reaktionsschritte
The resultant product from Example 47A (5 mmol) is mixed with 4-bromoimidazole (5 mmol), diethylamine (1 mL), bis(triphenylphosphine) palladium diacetate (0.1 mmol) and copper(I) iodide (0.1 mmol) in toluene. The mixture is stied at 25° C. until TLC analysis indicates the reaction is complete. The reaction mixture is concentrated in vacuo, and the residue is purified with column chromatography on silica gel to give the title product.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06221865B1 |
| Quelldatensatz | uspto-grants-2001_04 |
| ORD ID | ord-5ea27226ef3a42f78a7d8d7d2e59401e |
| Quellennotiz | uspto-grants-2001_04 |